17β-Estradiol Inhibits Inflammatory Gene Expression by Controlling NF-κB Intracellular Localization

-Estradiol Inhibits Inflammatory Gene Expression by Controlling NF- B Intracellular Localization

NF-κB increased expression of 17β-hydroxysteroid dehydrogenase 4 promotes HepG2 proliferation via inactivating estradiol.

Hepatocellular carcinoma (HCC) arises in a setting of chronic inflammation induced by inflammatory cytokines, such as nuclear factor-kappaB (NF-κB). HCC is a male-predominant cancer that can be attenuated by estradiol (E2) in vitro and in vivo. Although 17β-hydroxysteroid dehydrogenase 4 (HSD17B4) has been implicated as an estradiol-inactivating enzyme, and its promoter sequence contains two pu...

Intracellular C. neoformans modulates macrophage NF-κB signaling 1 MODULATION OF MACROPHAGE INFLAMMATORY NF-κB SIGNALING BY INTRACELLULAR CRYPTOCOCCUS NEOFORMANS

Cryptococcus neoformans (Cn) is a sporeforming, intracellular pathogenic yeast found in soil and other niches worldwide (1). Inhalation of spores is thus extremely common, allowing Cn to infect ~70% of children in urban environments (2). In most cases Cn infections do not present immediate clinical symptoms; rather, Cn is able to enter a chronic latent state that may last for many years by resi...

Astragaloside IV Inhibits NF-κB Activation and Inflammatory Gene Expression in LPS-Treated Mice

In this study we investigated the role of astragaloside IV (AS-IV), one of the major active constituents purified from the Chinese medicinal herb Astragalus membranaceus, in LPS-induced acute inflammatory responses in mice in vivo and examined possible underlying mechanisms. Mice were assigned to four groups: vehicle-treated control animals; AS-IV-treated animals (10 mg/kg b.w. AS-IV daily i.p....

Zc3h12c inhibits vascular inflammation by repressing NF-κB activation and pro-inflammatory gene expression in endothelial cells.

Endothelial activation characterized by the expression of multiple chemokines and adhesive molecules is a critical initial step of vascular inflammation, which results in recruitment of leucocytes into the sub-endothelial layer of the vascular wall and triggers vascular inflammatory diseases such as atherosclerosis. Although inhibiting endothelial inflammation has already been well recognized a...